Universidad Tecnológica de la Mixteca  



Admission Requirements

 Candidates should have a good knowledge of mathematics (algebra, arithmetic and trigonometry functions), general chemistry, organic chemistry, general concepts of biochemistry and physics, basic laboratory skills, and a good reading comprehension of academic English.
 In addition, applicants for this degree courseshould possess the following skills:
  • Ability to observe, abstract, analyze and synthesize
  • Ability to think and conduct in the laboratory using the scientific method
  • Ability to work collaboratively as part of a team and incorporate new ideas in the analysis of problems before making decisions
  • Ability to work effectively under pressure

Graduate Profile

 The graduate of the Master of Science in Natural Products and Foodscourse will be able to conduct independent research, teach at both undergraduate and graduate academiclevels, provide high quality consultancyin the area of foods and natural products chemistry, provide specific solutions to concrete problems by means of a professional final project, and have the ability to pursuea Ph.D. degree.

General Programme Objectives

 The general objective of the M.Sc. programme is to form specialists in the areas of chemistry, biochemistry, food engineering, food technologies, and nutrition. Students will have the opportunity to develop skills for thecharacterization of active principles, identification of trace contamination, evaluation of the functional properties of foods, and developingcommercial processes to obtain food with potential benefits for the health of consumers.
The general objective of the M.Sc. programme is to provide the students with a strong background in the areas of chemistry, biochemistry, food engineering, food technologies and nutrition.

Course Outline

Semester Subject Credits Content Bibliography
First semester Chemistry of Natural Products 8
1. Steroids
2. Terpenoids
3. Lipids and prostaglandins
4. Alkaloids
5. Phenols, natural dyes and pigments
- Medicinal Natural Products. A biosynthetic approach. Paul M. Dewick. John Wiley & Sons Ltd, 2002. England.
- Plant secondary metabolites. Occurrence, structure and role in the human diet. Alan Crozier. Michael N. Clifford, Hiroshi Ashihara, Blackwell Publishing Ltd, 2006. UK.
- Bioactive natural products. Detection, isolation, and structural determination. Edited by Steven M., Colegate, Russell J., Molyneux. CRC Press; 2008. USA.
- Natural products from plants. Leland J. Cseke, Ara Kirakosyan, Peter B. Kaufman, Sara L. Warber, James A. Duke, Harry L. Brielmann. Editorial CRC, Taylor and Francis. 2006, Second edition. USA.
- Bioactive compounds in foods. Edited by John Gilbert, Hamide Z.Șenyuya. Blackwell Publishing, 2008. UK.
Functional Foods 8
1. Introduction to functional foods
2. Functional foods and health
3. Groups of products
4. Antioxidants and their effect on health
- Essentials of functional foods. Mary K. Schmidl, Theodore P. Labuza. Aspen Publishers, Inc. 2000, USA.
- Functional foods. R. Chadwick et al. Springer, 2003, Germany.
- Foods antioxidants. Technological, toxicological, and health perspectives (Food Science and Technology). Edited by D. L. Madhavi, S. S. Deshpande, D. K. Salunkhe. Marcel Dekker, Inc. 1996, USA.
- Functional dairy products. Edited by Tiina Mattila-Sandholm, Maria Saarela. CRC Press, 2003, USA.
- Functional foods ingredients and nutraceuticals. Edited by John Shi. CRC Press, Taylor and Francis, 2007, USA.
Quantitative Chemical Analysis 10
1. Sample preparation
2. Analytical separations
3. Filtration and Preparative liquid chromatography
4. Quality assurance
- Análisis Químico. Métodos y técnicas instrumentales modernas. Francis Rouessac & Annick Rouessac. Publisher: McGraw Hill, 2003. Traducido de la quinta edición en francés.
- Instrumental methods in food analysis. Techniques and instrumentation in analytical chemistry. Vol 18. J. R. J. Paré & J. M. R. Bélanger. Elsevier 1997.
- Practical high performance liquid chromatography. Veronika R. Meyer. John Wiley & Sons, 2004. 4th edition.
- Química analítica moderna. David Harvey. McGraw Hill, 2002.
- Validation in chemical measurement. Paul De Bièvre & Helmut Günzler, Springer, 2005.
Reasearch Lab I 10
1. The culture of lab safety
2. Prudent planning of experiments
3. Evaluating dangers and risks in the laboratory
4. Managing chemical substances
5. Working with chemicals
6. Working with lab equipment
7. Waste disposal
- Prudent practices in the laboratory. Handling and disposal of chemical. National Research Council, National Academic Press, 1995.
- Chemistry. An industry-based laboratory manual. John Kenkel. CRC Lewis Publisher. 2000.
- A primer on quality in the analytical laboratory. John Kenkel. National. Science Foundation. 2000.
- Implementing quality in laboratory policies and processes. Using templates, project management, and six sigma. Donell R. Chrstian Jr. Stephanie Drilling. CRC Press Taylor and Francis Group. 2010.
Research Seminar I 8
1. Time management
2. Project objectives
3. Literature review
4. Successful working strategies
5. Communicating with others
6. Common problems
- Your research project. How to manage it. Andy Hunt, Rotledge, 2005.
- Research questions. Richard Andrews, Continuum, 2003.
- Your research project. A step-by-step guide for the first time researcher. Nicholas Walliman & Bousmaha Baiche, Sage Publications, 2001.
- The research project. How to write it. Fourth edition. Ralph Berry. Routledge Taylor and Francis Group. 2002.
Second semester Modern Instrumentation Methods 10
1. Mass spectrometry
2. Infrared and Ramen spectroscopy
3. UV/Vis spectrophotometry and atomic bsorption
4. Nuclear magnetic resonance of single and bi-dimensional 1H and 13C
- Mass spectrometry principles and applications. Edmond de Hofmann and Vincent Stroobant, third edition. John Wiley and Sons, 2007.
- Chemical analysis. Modern instrumentation and techniques. Francis Rouessac and Annick Rouessac, second edition. John Wiley and Sons, 2007.
- Handbook of analysis instruments. Semih Ötles, CRC Press, 2008.
- Modern Raman spectroscopy- A practical approach. Ewen Smith and Geoffrey Dent, John Wiley and Sons, 2005.
- Spectrometric identification of organic compounds. Robert M. Silverstein, Francis X. Webster & David J. Kimble, John Wiley and Sons, 2005, seventh edition.
- Raman spectroscopy for chemical analysis. Richard L. McCreery, Wiley Interscience, 2000.
Food Processing 10
1. Food properties and biochemical preservation
2. Traditional preservation technologies
3. Emerging preservation technologies
4. Quality control and food safety
- Food preservation techniques. Peter Zeuthen and Lief Bogh-Sorensen, First edition. CRC, 2003.
- Food processing technology. P. J. Fellows, Third edition. CRC, 2009.
- Emerging technologies for food processing. Da-Wen Sun, Publisher: Academic Press, 2005.
- Novel food processing technologies. Gustavo V. Barbosa-Canovas, Maria S. Tapia and M. Pilar Cano, First edition. CRC, 2004.
- Food processing handbook. James G. Brennan, Wiley-VCH, 2006.
Bioreaction Engineering 10
1. Applied enzymatic catalysis
2. Microbial growth and biomass production
3. Fermentation
4. Secondary metabolite production
5. Biotransformations
6. Design and scaling upof bioreactors
- Enzymes in food processing, Tilak Nagodawithana & Gerald Red, Academic Press, Third edition, 1993.
- Biochemical engineering fundamentals, James E. Bailey & David F. Ollis, Second edition. McGraw Hill International, 1986.
- Bioprocess engineering: basic concepts. M. Shuler, F. Kargi. Prentice Hall, 2002.
- Stereoselective biocatalysis, R. N. Patel, Marcel Dekker, Inc., 2000.
- Metabolic engineering of plant secondary metabolism, R. Verpoorte, A. W. Alfermann, Kluwer Academic, 2002.
Research Lab II 10
1. Introduction
2. Random sampling
3. Sample sizes and percentages
4. Sample size estimate
5. Stratified sampling
6. Relational estimators
7. Systematic sampling
8. Cluster sampling
- Sampling techniques. William Cochran, John Wiley and Sons, 1977.
- Sampling for analytical purposes. Pierre Gy, John Wiley and Sons, 1999.
- Sampling statistics. Wayne A. Fuller, Wiley, 2009.
- Statistical methods for food science. Introductory procedures for the food practitioner. John Bower. Wiley-Blackwell. 2009.
- Practical statistics for the analytical scientist. A bench guide. Stephen L. R. Ellison, Vicki J. Barwick, Trevor J. Duguid Farrand. Second edition. RSC Publishing, 2009
Research Seminar II 8
1. Key principles of academic writing
2. Structuring the document
3. Writing style
4. Tips and strategies
5. Understanding the research and writing process
6. The various components of a research project
7. Oral exam
- Writing up Your University Assignments and Research Project. A practical Handbook. Neil Murray & Geraldine Hughes, McGraw Hill, 2008.
- Your research project. How to manage it. Andy Hunt, Routledge, 2005.
- Research Projects and Research Proposals. A guide for scientist seeking funding. Paul G. Chapin, Cambridge University Press, 2004.
- Your Research Project: A step-by-step Guide for the First-Time Researcher. Nicholas Walliman. 2th edition. Sage Publications Ltd. 2005
Third semester Research Lab III 10
1. Choosing the right method of statistical analysis
2. Graphical methods
3. Distribution and data types
4. Basic statistical techniques
5. Inconsistent values in analytical data
6. Variance analysis (ANOVA)
7. Regression
- Practical statistics for the analytical scientist. A bench guide. Stephen R- Ellison, Vicky J. Barwick, Trevor J. Duguint Farrant, second edition. The Royal Society of Chemistry, 2009.
- Statistical analysis of designed experiments. Helge Toutenburg, Springer, 2002.
- Experimental Design Using ANOVA. Barbara G. Tabachnik and Linda S. Fidell. Duxbury Press. 2006.
- A practical guide to scientific data analysis. Livingstone D. John Wiley and Sons, LTD, Publication, West Sussex, 2009.
- Introduction to linear regression Analysis. Douglas C. Montgomery, Elizabeth A. Peck, G. Geoffrey Vining. 4th edition. Wiley-Interscience. 2007.
Research Seminar III 8
1. Writing during the research process
2. Writing the sections of a research project
3. Choosing a journal for publication
4. Final rewrite
5. Preparing and sending the manuscript
- From research to manuscript. A guide to scientific writing. Michael Jay Katz, Springer, 2009.
- MLA handbook for writers of research papers. The Modern Language Association, seventh edition, 2009.
- How to design a report experiments. Andy Field and Graham J. Hole. Sage Publication LTD, 2003.
- How to write and Illustrate a scientific paper. Bjorn Gustavii. Cambridge University, 2008.
- How to write and publish a scientific paper. Robert A. Day. 6th edition. Greenwood. 2006.
Fourth semester Research Lab IV 10
1. Effective experimental design
2. Validation and execution of the method
3. Uncertainty measurement
4. Analytical quality control
5. Statistical analysis using Excel MR
- Practical statistics for the analytical scientist: A bench guide. Stephen R. Ellison, Vicky J. Barwick, Trevor J. Duguint Farrant, 2th edition. The Royal Society of Chemistry, 2009.
- Statistical analysis with excelMR. Vijay Gupta, VJBooks, 2002.
- How to use excel in analytical chemistry and in general scientific data analysis. Robert de Levie, Cambridge University Press, 2004.
- Design and analysis of experiments. Angela M. Dean and Daniel Voss. Springer, 1998.
Thesis seminar 8
1. Beginning writing the thesis
2. Planning and writing references (bibliography)
3. Writing up materials and methods
4. Writing up results
5. Writing the introduction
6.Structure of the discussion
7. Figures and tables
8. Choosing a title and planning and writing preliminary and additional sections
9. Thesis format
10. Correction, printing binding and delivery
11. Viva examination
12. Supervision
- Enjoy writing your science thesis or dissertation. Daniel Holtom & Elizabeth Fisher, Imperial College Press, 1999.
- Guide to successful thesis and dissertation. A handbook for students and faculty. Fifth edition. James E. Mauch & Namgy Park, Marcel Dekker Inc., 2003.
- How to write a successful science thesis. The concise guide for students. William E. Russey, Hans F. Ebel & Claus Bliefert, Wiley-VCH, 2006.
- Writing the winning dissertation: A step-by-step guide. Allan A. Glatthorn. Corwin Press. Inc., 2005.

*Learning Activities
Teacher oral presentations, reading and discussion of scientific articles with specific examples of the topics of each subject, literature review, academic projects and essays, seminar presentations.
Revisiones bibliográficas, redacción de proyectos y ensayos, presentaciones de seminarios.
*Evaluation Criteria
Examinations, presentations, lab work and essays.

Student Enrollment

Cohort Number of Students
2010-2012 2
2012-2014 4
2013-2015 2
2014-2016 6
2015-2017 3
2016-2018 2


Dra. Norma Francenia Santos Sánchez

E-mail: nsantos@mixteco.utm.mx
 Dr. Santos obtained her undergraduate degree in Biological and Pharmaceutical Chemistry at the University of Veracruz, Xalapa. Work on her thesis "Total Synthesis of the isomeric furanocoumarins ()-2,3-dihydro-2-(1 ', 2'-dihydroxy-1'-methylethyl) -7H-furo [3,2-g] [1] benzopyran-7-ones ", was carried out at the Institute of Basic Scienceat the University of Veracruzin 1996, under the direction of Dr. Ricardo Miranda Tovar. She received her Doctorate in Organic Chemistry at the Chemistry Department of CINVESTAV-IPN in 2003, with the doctoral thesis: "Synthesis and Conformational Analysis of Alkaloids of Physostigmines", under the direction Dr. Sonia Martha Morales-Rios.
 Since 2003 she has been a research professor at the Agro-industrial Institute of the Technological University of the Mixteca.Her research areas involve the assessment, isolation and characterization of antioxidants from fruits and plant extracts. The plant material under study is indigenous to Oaxaca and Mexico and contributes to the chemical and functional knowledge of biodiversity. Another field of knowledge that she has developed has been the organic synthesis of heterocyclic compounds derived from quinoxalines, organic molecules with potential antioxidant and antimicrobial activity. Her synthesis proposal for obtaining these compounds is novel and versatile. Quantification of the antioxidant properties of the isolated metabolites, extracts or synthetic products of spectroscopic methods has been carried out. The employed methods are DPPH radical, ABTS, FRAP, and chelation.

Dr. Raúl Salas Coronado

E-mail: rsalas@mixteco.utm.mx
 Dr. Salas received his first degree in Chemical Engineering from the University of Veracruz, Poza Rica / Tuxpan. He holds a Ph.D. in Chemistry awarded by the Center for Research and Advanced Studies of IPN (CINVESTAV-Mexico). Since 2003 he has been Research Professor attached to the Agro-industrial Institute of the Technological University of the Mixteca. Dr. Salas has taught Physical Chemistry, Instrumental Analysis, Analytical Chemistry and the Thesis Seminar to undergraduates in Food Science as well as Quantitative Chemical Analysis and Modern Instrumental Methods in the Master of Science Program in Natural Food Products. Between 2004 and 2008 he was director of the Agro-Industrial Institute. From 2009 until 2013 he was the coordinator of the Master's Program in Natural Products and Food. From 2007 to 2011 he was also leader of the Chemical-Biology research group, which is currently in consolidation. His research is related to the study of natural products in plants and foods and evaluation of the effect of thermal processing on the composition of pigments and antioxidants in foods. He has supervised six undergraduate theses and is currently supervising two master's theses. He is a reviewer for the journals Food Research International y de Journal of Mexican Chemical Society. Dr. Salas is a member of the national scientific registry (CONACYT) of accredited evaluators in the field of Biology and Chemistry. He has attained the honor of Level 1 National Researcher awarded by the National System of Researchers (SNI) and a Distinction Profile awarded by the Secretariat of Education. He has been Academic Vice-Rector of the Technological University of the Mixteca since 2013.

Dr. Rogelio Valadez Blanco

E-mail: rvaladez@mixteco.utm.mx
 Dr. Valadez obtained a bachelor’s degree in Food Science at the Unidad Profesional Interdisciplinaria de Biotecnología at the Instituto Politécnico Nacional (IPN) where he graduated with honours in 2000. In 2003 he earned a master’s degree in Chemical Engineering and Applied Chemistry at the University of Toronto in Canada, under the direction of Dr.Levente Diosady. His master’s thesis, "In-line ColorMonitoringduring the Food Extrusion Process Using a CCD Spectrometer", was later published as a scientific article. In 2008 he earned his doctorate at Imperial College London (England) in the Department of Chemical Engineering, under the guidance of Dr. Andrew Livingston. His doctoral thesis was "Membrane Reactors for the Enantioselective Production of Organic Chiral Compounds Using Nanofiltration Membranes" and produced five scientific articles in international journals. Since 2009 he has been working at the Universidad Tecnológica de la Mixteca(UTM) in Huajuapan de León, Oaxaca, as a research professor in the BSc in Food Engineeringprogram. He participated in the creation of the MScin Natural Products and Foods program at UTM and is part of the Basic Academic Groupof the same program. Dr. Valadez is currently head of the BSc in Food Engineeringprogram. He holds a Promep profile and is the coordinator of the Bio-chemical Sciences academic group, UTMIX-CA-21. He has supervised four theses at the undergraduate level and one M.Scthesis. His current research focuses on the production and testing of biofertilizers on corn and tomato crops. He is also directing a research project on the microbiological and functional improvement of pulque in collaboration with Dr. Thomas Montville (RutgersUniversity, New Jersey) and Dr. Adelfo Escalante (IBT-UNAM). In addition,he is developing a project for the separation of flavonoids from plants and foodsextracts using nanofiltration membranes in collaboration with the CA-21group. Dr. Valadez is currently coordinating the project Research Networks of CAs of PROMEP: "The Development of an Integral System for the Cultivation of Tomatoes Employing Sustainable Methods", in which natural extracts and beneficial microorganisms are used for the control of phytopathogenicfungi in tomato crops.

Dra. Mirna Patricia Santiago Gómez

E-mail: patsanmx@mixteco.utm.mx
 Dr. Santiago is a Chemical Engineer with a speciality in Food Science. She graduated from the Instituto Tecnológico de Oaxaca where she also earned her master’s degree in Biochemical Engineering. She obtained a doctorate in Food Science at the University of Bourgogne in Dijon, France. Currently she is a Research Professor of the Agro-industrial Institute at the Universidad Tecnológica de la Mixteca (UTM). Dr. Santiago is a visiting professor of the Interdisciplinary Research Centre for Integral Regional Development – Oaxaca Unit, which forms part of the Instituto Politécnico Nacional (IPN). She holds a Promep profile. She has been recognized by the National System of Researchers (SNI) at Level I. She has published six articles in international magazines and has trained personnel. She has also edited articles and evaluated projects which have been submitted to Conacyt. She is the coordinator of a research group called The Science and Technology of Food which undertakes research in food science and technology. She teaches her speciality in the BSc Food Science program and the MSc Natural Products and Food program. She is currently carrying out the following lines of research: The hydroperoxidelyase enzyme: extraction, purification, characterisation and use in the production of food aromas (aldehydes); The identification and transfer of small volatile migrant molecules of Braheadulcis in a model food system: a contribution to the assessment of the genuine cheeses of Mexico; The microbiological evaluation of agave inulin and the determination of the shelf life of prebiotic drinks.

Dra. Paula Cecilia Guadarrama Mendoza

E-mail: pcgm@mixteco.utm.mx
 Dra. Paula Cecilia Guadarrama Mendoza was born in Mexico City on 10 October 1972. She received her basic education at the Liceo Mexicano Japonés. In 1991 she entered the Food Studies Program in the Chemistry Department at UNAM. She completed her degree in 1997 with the thesis entitled "Estudio de factibilidad técnica para la obtención de pigmentos a partir de cefalotórax de camarón" ("A Study of the Technical Feasibility of Pigment Extraction from the Cephalothorox of Shrimp") under the direction of Dr. María Del Carmen Durán Domínguez. In 1997 she began work on her Master’s Degree in Food Science and Technology at the UAQ, completing the degree in October 1999 with the work "Estudio de la principal proteasadigestiva de Prostephanustruncatus (Horn)" ("A Study of the Main Digestive Protease of Prostephanustruncatus (Horn)")under the direction of Dr. Alejandro Blanco Labra of the CINVESTAV-Irapuato. Subsequently in 2000 she entered the Universidad Tecnológica de la Mixteca (UTM) as research professor in the Agro-Industrial Institute, where she continues working at present. Over the course of the past years she has given various courses related to the areas of Food Chemistry, Microbiology, Biochemistry and Sensory Evaluation of Food, helping also in the Food Engineering program. She has given training courses and workshops in the area of Food Chemistry and Preparation directed respectivelyat professors and those managers for the social program Albergues Escolares for indigenous people. She has participated in various national and international conferences. In 2013 she obtained the degree of Doctor in Sciences of Bioprocesses with the work "Productividad y caracterización de cepasparentales e híbridas provenientes de neohaplontes compatibles de Pleurotus spp. de la región mixteca" ("Productivity and Characterization of Related Families and Hybrids of Compatible Neohaplonts of the Pleurotus spp. from the Mixtec Region") under the direction of the Dr. Gustavo Valencia del Toro of the UPIBI-IPN. She has directed theses and published articles related to the area of food biotechnology. Currently she is developing projects related to the characterization of fungal families with dietary, functional, medicinal, or bio-remedial potential.

Dra. Edith Graciela González Mondragón

E-mail: edith@mixteco.utm.mx
 Dr. Edith Graciela González Mondragónhas a Doctorate in Chemical Sciences from the UAM-UnidadIztapalapa in the area of Protein Biophysical Chemistry. She obtained a postdoctoral fellowship of three years in the Medical Program at UNAM in the Department of Microbiology and Parasitology in the Laboratory of Parasitical Molecular Biology. Her research includes: 1) Structural characterization of the stability and catalytics of recombinable enzymes, 2) Application of agro-industrial plants and waste for the extraction and characterization of compounds such as flavonoids, 3) Extraction of polyphenol cyclodextrin compounds for possible application in the production of functional dietary substances, 4) Study of alternative sources of starch for the enzymatic synthesis of cyclodextrin, and 5) Isolation of micro-organisms with cyclodextringlycosyltransferase (CGTase) or feruloylesterase (FE) activity. She won the Twentieth Annual Research Award Competition in 2011 in the Area of Basic Sciences and Engineering through UAM with her work entitled Binding Thermodynamics of phosphorylated inhibitors to triosephosphateisomerase and the contribution of electrostatic interactions. She also has an award in the category of Technological Research in the State Awards of 2011, through the Science and Technology Board of Quintana Roo - State Government of Quintana Roo.

Dra. Beatriz Hernández Carlos

E-mail: bhcarlos@mixteco.utm.mx
 Beatriz Hernandez Carlos is a graduate of the Nacional School of Biological Sciences of the Instituto Politécnico Nacional with a major in Industrial Pharmaceutical Chemistry (1987) and a Master’s Degree in Bio-organic Chemistry (2005). She obtained her Doctorate in Chemical Sciences from the Chemistry Department of the National Autonomous University of Mexico in 2000.
She worked in the pharmaceutical industry as an Analytical Chemist from 1989 to 1992, as Head of Quality Control (1992-1993) and as Head of New Product Development (2000).
She was an associate professor in the Interdisciplinary Biotechnology Professional Unit, IPN, Mexico City (1993-2002) and a research professor at the Resource Institute at the University of the Sea, Oaxaca (2002-2013). She is currently a research professor at the Universidad Tecnológica de la Mixteca (UTM) since September of 2013.
Dr. Hernandez’s research areas are: 1) the identification of vegetable species in the southern mountains and coastal areas of the state of Oaxaca with potential applications in medical science, food science and environmental science, and 2) the isolation, structural elucidation and biological evaluation of natural products with polar properties (glycosides).
She has directed five undergraduate theses and four master’s theses. She has published 17 articles in indexed periodicals and four book chapters, and she has presented 26 papers at professional conferences. She is a member of the National Researchers’ System Level I (2005-2015) and the recipient of the 2013 State Prize in Science, Technology and Innovation in the area of Biological Sciences awarded by the Oaxacan Council of Science and Technology.

Dra. Claudia Villanueva Cañongo

E-mail: claudiavc@mixteco.utm.mx
 Es ingeniero en Alimentos por la Universidad Tecnológica de la Mixteca, con la tesis profesional intitulada: Caracterización parcial y conservación de la pulpa del fruto de Cyrtocarpa procera por métodos combinados. Parte de este trabajo se publicó en el 2010: Marco Vinicio Ramírez-Mares, Claudia Villanueva-Cañongo, Carlos Guillermo Hernández. Proximate composition and preservation by combined methods of chupandia (Cyrtocarpa procera) pulp. Pak. J. Nutr. 2010, 9(1), 1. Tiene el grado de Maestra y Doctora en Ciencias Quimicobiológicas con especialidad en Química de Productos Naturales por la Escuela Nacional de Ciencias Quimicobiológicas-IPN (ENCB-IPN) con las Tesis de Maestría y Doctoral: Caracterización de los metabolitos secundarios de Senecio polypodiodes y Análisis estructural de los metabolitos secundarios de tres especies del género Senecio, respectivamente. Parte de este trabajo se publicó en el 2014: Claudia Villanueva-Cañongo, Nury Pérez-Hernández, Beatriz Hernández-Carlos, Ernestina Cedillo-Portugal, Pedro Joseph-Nathan, Eleuterio Burgueño-Tapia. Complete 1H NMR assignments of pyrrolizidine alkaloids and a new eudesmanoid from Senecio polypodioides. Magn. Reson. Chem. 2014, 52(5), 251. Actualmente realiza una estancia Posdoctoral dentro del cuerpo académico Ciencias Químico-Biológicas en colaboración con la Dra. Beatriz Hernández Carlos, en química de productos naturales, en el proyecto de investigación: Obtención de compuestos a partir de dos especies vegetales con potencial biológico. El presente proyecto se desarrolla con el propósito de aportar datos nuevos al conocimiento científico de la flora autóctona del estado de Oaxaca, planteándose como objetivo general, obtener los componentes químicos principales de las plantas Alloispermum integrifolium y Prostechea varicosa, especies a las que se les reconoce popularmente como plantas medicinales. Actualmente cuenta con tres publicaciones en revistas indizadas. La Dra. Villanueva-Cañongo ha impartido el curso práctico de aplicación de la cromatografía de líquidos en el estudio de los Productos Naturales, así como la materia de Procesado de Alimentos en la Maestría en Ciencias: Productos Naturales y Alimentos.

The Masters Program's Generation and Application of Knowledge

1. Characterization, production, measuring and monitoring secondary metabolites

 In this area, projects are developed related to the extraction, separation, and identification of chemical compounds with bioactivity. General extraction methods are used such as liquid-liquid or solid-liquid extraction. Some of the extraction techniques used imply maceration, Soxhlet extraction, extraction assisted by microwaves or ultrasound, as well as solid-phase microextraction. For separation, ultra and nano membrane filtration methods are used, as well as chromatographic methods of liquids or gases with simple detection. The filtration membranes are used to refine the extracts prior to using the chromatographic techniques. For high-performance liquid chromatography, UV/Visible, refractive index and fluorescent detectors are used. For gas chromatography (GC) flame ionization detectors (FID) and electron capture detectors are routinely used. Identification is done by low- and high-resolution mass spectrometry, infrared spectroscopy (IR), one- and two-dimensional 1H y 13C nuclear magnetic resonance (NMR), and even x-ray diffraction. For quantifying the chemical compounds of interest, the GC-EM-EM and HPLC hyphenated technique with the aformentioned detectors are used. Additionally, organic syntheses for obtaining compounds with bioactivity are carried out, as well as the development and implementation of enzymatic and fermentative methods for the production and monitoring of products of interest.

2. Engineering of Sustainable Biotechnological Processes

 This aims to develop projects that could potentially be used in the food and pharmeceutical industries. It is related to the development of biotechnological processes to reduce the level of organic contaminants from agro-industrial liquid waste, involving physico-chemical and/or biological treatment. Among the physico-chemical treatments is ozonation, while the biological treatments can be aerobic, anaerobic or facultative. These processes are oriented chiefly toward the generation of products of commercial interest, for example: biomass, biogas, probiotics derived from agave and phenolic compounds. The latter are of particular interest, due to the fact that they have a high added value due to their antioxidant activity, which is associated with the prevention of cancer and cardiovascular and neurodegenerative conditions. This line is also associated with the enzymatic production of scents derived from aldehyde and esters.


Student Thesis Director Academic Counselor
I.A. Nancy Girón Cruz Dr. Raúl Salas Coronado Dr. Rogelio Valadez Blanco
I.A. Analleli Jiménez Durán Dr. Raúl Salas Coronado Dra. Norma Francenia Santos Sánchez
I.A. Stefi Castillejos Márquez Dr. Vania Robles Gonzáles Dr. Raúl Salas Coronado
I.A. Armando Torralba González Dra. Edith Graciela González Mondragón M.C. Alma Yadira Salazar Govea
I.Q.I. Joseoziel Llaguno Guilberto Dra. Norma Francenia Santos Sánchez Dra. Edith Graciela González Mondragón
I.I.A. Dora Jhanina Rodríguez Fernández Dra. Norma Francenia Santos Sánchez Dra. Beatriz Hernández Carlos

Relevant Academic Production


Chemical composition, color, and antioxidant activity of three varieties of Annona diversifolia Safford fruits. Industrial Crops and Products. 2011, 34, 1262-1268. Julián-Loaeza, A. P., Santos-Sánchez, N. F., Valadez-Blanco, R., Sánchez-Guzmán, B. S., Salas-Coronado, R.
Chemical and pharmacological aspects of capsaicin. Review. Molecules. 2011, 16, 1253-1270. Maria de Lourdes Reyes-Escogido, Edith G. Gonzalez-Mondragon, Erika Vazquez-Tzompantzi.
Bioactive saponins from Microsechium helleri and Sycios bulbosus. Phytochemistry, 2011, 72, 743-751. Hernández-Carlos, B., González-Coloma, A., Orozco-Valencia, A. U., Ramírez-Mares, J. M. V., Andrés-Yeves, Ma. Fe, Joseph-Nathan, P.
Antibacterial activity of crude extracts from Mexican plants against methicillin-resistant Staphylococcus.African Journal of Biotechnology. 2011, 10, 13202-13218. Rocha-Gracia, R. C., Hernández-Arroyo, M.M., Lozano-Zaraín, P., Hernández-Carlos, B., Santiago-Romero, H., Cedillo-Portugal, E., Zayas-Pérez, M. T., López-Olguín, J. F.
Screening of antitopoisomerase, antioxidant, and antimicrobial activities of selected triterpenes and saponins. Revista Latinoamericana de Química. 2012, 40, 165-177. Herrera-Martínez, M., Mirón-Enríquez, C., Hernández-Carlos, B., Cedillo-Portugal, E., Ramírez-Mares, M.V., Burgueño-Tapia, E.
Effect of rotating tray drying on antioxidant components, color and rehydration ratio of tomato saladette slices. LWT Food Science and Technology. 2012, 46, 298-304. Santos-Sánchez, N. F., Valadez-Blanco, R., Gómez-Gómez, M. S., Pérez-Herrera, A., Salas-Coronado, R.
Treatment of mezcal vinasses: A review. Journal of Biotechnology. 2012, 157, 524–546. Vania Robles-González, Juvencio Galíndez-Mayer, Noemí Rinderknecht-Seijas, Héctor M. Poggi-Varaldo.
The artisanal production of pulque, a traditional beverage of the Mexican highlands. Probiotics and Antimicrobial Proteins. 2012, 4, 140-144. Valadez-Blanco, R.; Bravo-Villa, G., Santos-Sánchez, N. F., Velasco-Almendarez, S. I., Montville, T. J.
Effects of a buried cysteine-to-serine mutation on yeast triosephosphate isomerase structure and stability. International Journal of Molecular Science. 2012, 13, 10010-10021. Alejandra Hernández-Santoyo, Lenin Domínguez-Ramírez, Cesar A. Reyes-López, Edith González-Mondragón, Andrés Hernández-Arana, Adela Rodríguez-Romero.
Biochemical characterization of recombinant L-asparaginase (AnsA) from Rhizobium etli, a member of an increasing Rhizobial-type family of L-asparaginases. Journal of Biotechnology. 2012, 22, 292-300. Moreno-Enríquez A., Evangelista-Martínez Z., González-Mondragón E.G., Calderon-Flores A., Arreguin R., Perez-Rueda E., Huerta-Saquero A.
Transformación DDT en el ambiente en Mitos y Realidades del DDT. Universidad del Mar, 2012, ISBN 978-607-95266-2-7. (Capítulo de libro) Hernández-Carlos, B.
Métodos de detección y cuantificación del DDT y de sus productos de degradación en Mitos y Realidades del DDT. Universidad del Mar, 2012. ISBN 978-607-95266-2-7. (Capítulo de libro) Hernández-Carlos, B.
Factors affecting the antioxidant content of fresh tomatoes and their processed products. En: Tomatoes: Cultivation, varieties and nutrition. 2013, Editorial Nova Science Publishers, 191-212. (Capítulo de libro) Norma Francenia Santos-Sánchez, Rogelio Valadez-Blanco, Raúl Salas Coronado.
Estudio comparativo de las propiedades fisicoquímicas y nutrimentales de almidón obtenido a partir de dos especies de malanga (Colocasia antiquorum y Colacasia esculenta) cultivadas en el estado de Oaxaca. En memorias del Congreso Internacional Academia Journals Celaya. 6-8 noviembre 2013. Celaya, Guanajuato. ISSN 1946-5351. Vol. 5, No. 3, pp 1382-1387. González Mondragón Edith Graciela, Betancur Ancona David, Ríos Río Karina Lilibeth, Ramírez Jiménez Mariela.
Complete 1H NMR assignments of pyrrolizidine alkaloids and a new eudesmanoid from Senecio polypodioides. Magnetic Resonance in Chemistry. 2014, 52, 251–257 Villanueva-Cañongo, C., Pérez-Hernández, N., Hernández-Carlos, B., Cedillo-Portugal, E., Joseph-Nathan, P., Burgueño-Tapia, E.
Polyphenolic content, free radical-scavenging activity and isolation of tiliroside from Heliocarpus terebinthinaceus (Tiliaceae) seeds. Journal of Biological Science. 2014, 14 (5), 376-380. ISSN 1727-3048. DOI: 10.3923/JBS.2014.376.380. Santos-Sánchez, N. F.; Flores-Parra, A.; Valadez-Blanco, R.; Fernández-Rojas, B.; Martínez-Vásquez, J. B.; Salas-Coronado, R.
Antimicrobial effect of crude plant extracts of some Mexican flora from Oaxaca. Frontiers in Microbiology. 2014, doi: 10.3389/fmicb.2014.00383. Lira-De León, K. I., Ramírez-Mares, M. V., Sánchez-López, V., Ramírez Lepe, M., Salas-Coronado, R., Santos-Sánchez, N. F., Valadez-Blanco, R., Hernández-Carlos. B.
Morphology and mycelial growth rate of Pleurotus spp. strains from the mexican mixtec region. Brazilian Journal of Microbiology. 2014, En revision arbitral. P. C. Guadarrama-Mendoza, G. Valencia del Toro, R. Ramírez-Carrillo, F. Robles-Martínez, J. Yañez-Fernández, M. E. Garín-Aguilar, C. G. Hernández, G. Bravo-Villa.
Adaptation of a Bacillus licheniformis biofertilizer strain to a molasses-enriched medium for increased production. Journal of Applied Microbiology. 2014, En revision arbitral. Luis Erick Mota-Pacheco, Adelfo Escalante, Raúl Salas-Coronado; Norma Francenia Santos-Sánchez, Thomas J. Montville, Rogelio Valadez-Blanco.
Thermodynamic properties of simple multi-Yukawa fluids: A variational approach. Revista Mexicana de Física. E, 2011, 57, No.1. J. N. Herrera, A. Y. Salazar-Govea, A. Cruz- Vera, E. González-Jiménez.
Los líquidos y otros estados de la materia. Boletín de la Vicerectoría de Investigación y Estudios de Posgrado de la BUAP. 2011, Año 2, Núm. 17. J. N. Herrera, A. Y. Salazar, A. M. Aguilar.
Aislamiento y obtención de híbridos de cepas nativas de Pleurotus spp. de la región mixteca.
ISSN: 1870-0160, Revista de Salud Pública y Nutrición, 2011, 6, 765-772.
Guadarrama Mendoza P. C., Valencia del Toro, G., Morales Bajío, B., Hernández C. G., Bravo-Villa G., Garín Aguilar M. E.
Pulpa del fruto de Cyrtocarpa procera conservada por métodos combinados.
ISSN: 1870-0160, Revista de Salud Pública y Nutrición, 2011, 6, 670-677.
Villanueva Cañongo Claudia, Hernández Carlos Guillermo, Guadarrama Mendoza Paula Cecilia.
Caracterización micelial de cepas parentales, neohaplontes e híbridas de Pleurotus spp. de la región mixteca.
ISSN: 0370-594, Revista Latinoamericana de Química, 2012, vol. 39, 106-107.
Guadarrama-Mendoza Paula Cecilia, Valencia del Toro Gustavo, Ramírez Carrillo Rebeca, Robles Martínez Fabián, Garín Aguilar María Eugenia, Salas Coronado Raúl.
Determinación de un método para la obtención de residuos fibrosos con mayor contenido de fibra dietética soluble.
ISSN 1870-0160. Revista Salud Pública y Nutrición. 2012, 2, 471-474.
López Luna J., Priego Mendoza, N. Santiago Gómez M. P., Betancur Ancona D.


Title/Conference Authors
Post-graduate student and basic academic core teacher participation
Optimización de un proceso de biorreactor para el crecimiento de Azospirillum spp. utilizando melazas como fuente de carbono.
46° Congreso Mexicano de Química, Querétaro, Querétaro, México, 10 al 14 de septiembre del 2011.
Luis Erick Mota Pacheco, Rogelio Valadez Blanco
Evaluación del efecto del número de ciclos y potencia en la extracción asistida por microondas de fenoles y flavonoides de semillas de H. terebinthinaceus”. Presentado en el XLVI Congreso Mexicano de Química, celebrado en la Ciudad de Querétaro, Querétaro, del 10 al 14 de septiembre del 2011. Bol. Soc. Quím. Méx. 2011, 5, C/83, 86 Sahadi Itzel López-Urbina, Norma Francenia Santos-Sánchez, Raúl Salas-Coronado
Evaluación de la producción de biomasa de Azospirillum spp. empleando melazas como fuente de carbono.
13° Feria de Posgrados, Conacyt. Ensenada, B. C.; Toluca, Estado de México; y Mérida, Yucatán. 12 al 16 de marzo del 2012.
Luis Erick Mota Pacheco, Rogelio Valadez Blanco
Deshidratado de mango, pretratado con metabisulfito de sodio, en un secador de charolas giratorias minimizando la degradación de sus propiedades funcionales.
IV Jornada de Ingeniería en Alimentos, UTM, Huajuapan de León, Oaxaca. 18 octubre del 2012.
Analleli Jiménez Durán, Raúl Salas Coronado
Dulce a base de mango Tommy Atkins (Mangifera indica L) deshidratado pretratado con metabisulfito de sodio al 1%.
IV Jornada de Ingeniería en Alimentos, UTM, Huajuapan de León, Oaxaca. 18 octubre del 2012.
Analleli Jiménez Durán, Itzel Leyva Daniel, Karina Lilibeth Ríos Ríos, Raúl Salas Coronado
Evaluación del efecto de los sulfitos sobre el contenido de β-caroteno, fenoles y vitamina C en la deshidratación del mango Tommy Atkins.
14° Feria de Posgrados, Conacyt. Colima, Colima; Cuernavaca, Morelos; Chihuahua, Chihuahua y Distrito Federal. 19 al 26 de abril del 2013.
Analleli Jiménez Durán, Raúl Salas Coronado
Implementación de un método para la cuantificación de sulfitos en alimentos comerciales.
48° Congreso Mexicano de Química, Guanajuato, Guanajuato, México, 31 agosto al 4 de septiembre del 2013.
Analleli Jiménez Durán, Raúl Salas Coronado
Obtención de lacasa a partir de vinazas mezcaleraz y pellets dobles formados a partir de bagazo de agave espadín-Trametes versicolor o Pleurotus spp.
SIAB 2013 Simposium Internacional Agroalimentario y Biotecnológico, Bahías de Huatulco, Oaxaca, México. 19 de octubre del 2013.
Vania Shuhua Robles González, Stefi Castillejos Márquez; Ireri Victoria Robles González; Edith Graciela González Mondragón
Uso de pellets dobles formados con Trametes versicolor o Pleurotus spp. y polvo de agave espadín para la remoción de materia orgánica presente en vinazas de origen mezcalero.
VIII Congreso Internacional de Ingeniería Bioquímica, XIX Congreso Nacional de Ingeniería Bioquímica, XII Jornadas Científicas de Biomedicina y Biotecnología Molecular, Mazatlán, Sinaloa, México. 9-11 de abril del 2014.
Stefi Castillejos Márquez, Ireri Victoria Robles González, Edith Graciela González Mondragón, Vania Shuhua Robles González
Análisis termodinámico del encapsulamiento del ácido ferúlico con ciclodextrinas.
10ª Reunión Internacional en Productos Naturales, Mérida, Yucatán. 21-24 de mayo del 2014.
Torralba González Armando, Zubillaga Luna Rafael A., Robles González Vania S., González Mondragón Edith G
Contenido de compuestos antioxidantes en rebanadas deshidratadas de mango Tommy Atkins, pretratadas con extracto de sus semillas y sulfitos.
49° Congreso Mexicano de Química, Mérida, Yucatán, México, 17-21 de septiembre del 2014.
Analleli Jiménez Durán, Raúl Salas Coronado
Evaluación de la actividad antioxidante de extractos polares de Justicia spicigera.
49° Congreso Mexicano de Química, Mérida, Yucatán, México, 17-21 de septiembre del 2014.
Nancy Girón Cruz, Raúl Salas Coronado


Participation of basic academic core professors
Actividad antitopoisomerasa y antimicrobiana in vitro de 1,2,3,4-tetrahidroquinoxalin-2-onas.
XLVI Congreso Mexicano de Química, celebrado en la Ciudad de Querétaro, Querétaro, del 10 al 14 de septiembre del 2011. Bol. Soc. Quím. Méx. 2011, 5, trabajo oral 15, 80
Norma Francenia Santos-Sánchez, Marco Vinicio Ramírez-Mares, Jorge Alberto Sánchez-Burgos, Angelina Flores-Parra, Raúl Salas-Coronado
Cuantificación de alcaloides, fenoles y flavonoides totales en extractos de hojas de Ipomoea murucoides.
XLVI Congreso Mexicano de Química, celebrado en la Ciudad de Querétaro, Querétaro, del 10 al 14 de septiembre del 2011. Bol. Soc. Quím. Méx. 2011, 5, C/EST 42, 94.
Magdalena Paz Oropeza Guerrero, Norma Francenia Santos-Sánchez, Raúl Salas-Coronado
Antidiabetic activity in vitro and total flavonoids content in Persea americana (avocado) leaves and Colubrina elliptica bark.
5th International Conference on Advanced Technologies & Treatments for Diabetes, Barcelona, Spain, February 8-11, 2012.
José Adrián Cruz-Gallegos, Rogelio Valadez-Blanco, Norma Francenia Santos Sánchez, Raúl Salas-Coronado
Caracterización proximal, contenido de fenoles y flavonoides totales y actividad antioxidante de semillas de Annona purpurea.
XLVIII Congreso Mexicano de Química, celebrado en la Ciudad de Guanajuato, Guanajuato del 31 de agosto al 4 de septiembre del 2013. Bol. Soc. Quím. Méx. 2013, 7, QPNT/E3 C, 204.
Miriam Sara Hernández González, Norma Francenia Santos Sánchez, Raúl Salas Coronado.
Efecto de un biofertilizante a base de Bacillus spp. en la productividad y composición química proximal de frutos de jitomate.
4° Congreso Internacional de Biología, Química y Agronomía, celebrado en la ciudad de Zapopan, Jalisco, México, los días 25 a 27 de septiembre del 2013.
Norma Francenia Santos Sánchez, Fidencio Sustaita Rivera, Abimael López Hernández, Vicencio Cuevas Mendoza, Raúl Salas Coronado, Rogelio Valadez Blanco
Efecto antifúngico de algunas especies vegetales de la flora Oaxaqueña.
4° Congreso Internacional de Biología, Química y Agronomía, celebrado en la ciudad de Zapopan, Jalisco, México, los días 25 a 27 de septiembre del 2013.
Karla Isabel Lira de León, Marco Vinicio Ramírez Mares, Joana Tzetzangari Santiago Martínez, Raúl Salas Coronado, Norma Francenia Santos Sánchez, Rogelio Valadez Blanco, Vladimir Sánchez López, Beatriz Hernández Carlos
Determinación nutrimental de larvas y pupas de Ticoco.
VI Simposio Internacional de Ciencia y Tecnología de Alimentos. Villahermosa, Tabasco, México. 10-14 de Septiembre de 2012.
López Hernández Abimael, Salazar Govea Alma Yadira, Santiago Gómez Mirna Patricia, González Mondragón Edith Graciela
Análisis proximal del gusano Cuetla (Arsenura armida).
VI Simposio Internacional de Ciencia y Tecnología de Alimentos. Villahermosa, Tabasco, México. 10-14 de Septiembre de 2012.
García Cortés Mónica Yoselín, Salazar Govea Alma Yadira, Barrera García V. Daniela

Outreach to other Sectors of Society

  • Participation in annual refresher courses for upper secondary education teachers.
  • Chemical, microbiological, and sensory studies for businesses that commercialize agave products.
  • The development and implementation of aerobic technologies for the treatment of municipal wastewater.
  • Evaluation of the chemical and functional quality of fresh and processed food.

Administrative processes

El proceso de admisión

 Para la admisión de los alumnos al posgrado MCPNyAl se realiza la secuencia siguiente:
  • Presentación de un examen de conocimientos para su ingreso al propedéutico. Este examen comprende las materias de Bioquímica, Química de alimentos, Matemáticas, y Química Orgánica (se adjunta guía de estudios).
  • Entrevista por parte del comité de admisión, formado por tres miembros del núcleo académico básico (NAB). Donde se evalúan cuatro aspectos: a) Trayectoria académica/profesional y metas profesionales; b) Capacidades personales y habilidades de trabajo experimental; c) Actitudes para trabajo de investigación y estudios de posgrado; y d) Intenciones de inversión de tiempo en el programa de maestría. Se adjunta formato de entrevista. Se publican las fechas para la presentación de exámenes y entrevista.
  • Con base en los resultados del examen de conocimientos y la entrevista se seleccionan los alumnos que participarán en el propedéutico, el resultado se les hace llegar por escrito desde la División de Estudios de Posgrado. En el curso propedéutico se estudian las materias Bioquímica, Química de Alimentos, Matemáticas, y Química Orgánica. Este curso propedéutico es de ocho semanas y se imparte por profesores del NAB, y se evalúan los conocimientos al final de los cursos. El profesor encargado de la materia imparte cursos, analizan artículos científicos relacionados con el tema, según sea el caso. En algunas ocasiones los alumnos llegan a presentar algún tema. Durante este curso propedéutico se realizan exámenes parciales, para un monitoreo del avance académico de los alumnos. Y al final del curso propedéutico se aplica el examen final que permitirá la selección definitiva de los alumnos al programa de posgrado. Esta selección es realizada por el comité de admisión del núcleo académico básico y se analizan los resultados de los exámenes finales las materias y su entrevista. Se redacta un acta de admisión que se hace llegar a la División de Estudios de Posgrado.
  • A los alumnos admitidos se les comunica por escrito el dictamen de admisión, oficio que firma el jefe de la División de Estudios de Posgrado.


Application and submission of documents February 23th - June 30th 2017
Admission exam July 5th 2017
Interview July 6th 2017
Preparatory Course Enrollment July 14th – 28th 2017
Preparation Course     July 31th – September 22th 2017

Requirements for processing enrollments

  • Two recent copies of the applicant's birth certificate
  • Two copies of the Bachelor's degree certificate
  • Two copies of professional certification (if you do not have professional certification, bring an academic transcript or other documentation from your university, showing that you have the option of qualifying through credits for Masters courses)
  • Two copies of your professional license
  • A letter outlining your reasons for enrolment in this course
  • Your résumé
  • Six black-and-white passport-size photographs
  • Two letter of reference
Note:All documentation (both original and copies) must be handed in on letter-sized paper, along with the fee for the Entry exam.



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 Carretera Huajuapan Acatlima Km. 2.5, Huajuapan de León, Oax., México, C.P.69000 División de Estudios de Posgrado y Departamento de Servicios Escolares. Tel. y Fax. (953) 53 2 03 99 ext. 300, 110 y 768, e-mail.- posgrado@mixteco.utm.mx, Servicios Escolares; escolar@mixteco.utm.mx



Coordinador Académico
E-mail: @mixteco.utm.mx
Teléfono: (953) 532 03 99
Dr. José Aníbal Arias Aguilar
Jefe de la División de Estudios de Posgrado
E-mail: anibal@mixteco.utm.mx
Teléfonos: 953 532 03 99/202 14 Ext. 768



































The Oaxaca System of State Universities
Carretera a Acatlima Km. 2.5 Huajuapan de León, Oax., México C.P. 69000